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2022 Cranefield Awardees

Paul F. Cranefield Award

Polina Lishko
for “The epithelial potassium channel Kir7.1 is stimulated by progesterone”

Patch clamp electrophysiology studies of choroid plexus epithelial cells by Lishko and colleagues reveals a progesterone-activated potassium current, which the authors demonstrate is due to the Kir 7.1 channel, elucidating a molecular mechanism of sex steroid hormone regulation at the blood-brain barrier.

Cranefield Postdoctoral Fellow Award

Fayal Abderemane-Ali
for “Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins”

Abderemane-Ali and colleagues show that the primary driver of poison-resistance in poisonous organisms might be sequestration by ‘toxin sponge’ proteins rather than mutations in the endogenous voltage-gated sodium channels, as previously believed.

Cranefield Student Award

Colline Sanchez
for “Detection of Ca2+ transients near ryanodine receptors by targeting fluorescent Ca2+ sensors to the triad"

Sanchez and colleagues develop a novel approach to directly detect sarcoplasmic reticulum Ca2+ release triggered by activation of the voltage dependent CaV1.1 channel and find that spatially distinct triadic regions exhibit remarkable uniformity in terms of onset and termination of Ca2+ release.  

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Journal of General Physiology and the Society of General Physiologists have a close and long-standing collaborative relationship dedicated to promoting the study of fundamental biological mechanisms through comprehensive, systematic and quantitative investigation.

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