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2021 Cranefield Awardees

Paul F. Cranefield Award

Federico F. Trigo for "Differentially poised vesicles underlie fast and slow components of release at single synapses
Journal of General Physiology 152 (5) e201912523; DOI:

Trigo and colleagues used cutting edge biophysical techniques to show how that the prior elevation affects of Ca2+ release probability of vesicles that fuse with high or low latency, a phenomenon of critical importance for understanding the effects of conditioning stimulation.

Cranefield Postdoctoral Fellow Award

Martin L. Prieto for "Spike frequency–dependent inhibition and excitation of neural activity by high-frequency ultrasound" Journal of General Physiology 152 (11) e202012672; DOI:

Prieto and colleagues show that ultrasound waves can increase potassium conductance eliciting competing inhibitory and excitatory effects on action potential firing, possibly via local increases in tissue temperature and in cell membrane tension.

Cranefield Graduate Student Award

Cassandra L. Hays for "Resting and stimulated mouse rod photoreceptors show distinct patterns of vesicle release at ribbon synapses" Journal of General Physiology 152 (12): e202012716; DOI:

Hays and colleagues report the unexpected finding that at the resting potential in darkness rods photoreceptor cells release coordinated bursts of glutamate-filled suggesting that this behavior may have a role in transmitting dim-light responses.


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Journal of General Physiology and the Society of General Physiologists have a close and long-standing collaborative relationship dedicated to promoting the study of fundamental biological mechanisms through comprehensive, systematic and quantitative investigation.

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