The Paul F. Cranefield Award was created by the Council of the Society of General Physiologists to honor Paul F. Cranefield, M.D., Ph.D., who for 30 years served as Editor of Journal of General Physiology. The Award is meant to recognize an independent young investigator who in the preceding calendar year has published an outstanding article in the Journal. It further was stipulated that the Award need not be given every year, that it should be reserved for a truly noteworthy paper. To qualify for this Award, the work being recognized must have been completed within 10 years of the candidate’s first independent position, but the committee will continue to prioritize awards to more junior candidates when available.
2023 Paul F. Cranefield Awardee: Ivy Dick, Ph.D.
Ivy E. Dick for “CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms”
J Gen Physiol (2022) 154 (11): e202213209. https://doi.org/10.1085/jgp.202213209
Dick and colleagues show that mutations in the Cav1.2 channel in patients affected by Timothy syndrome 2 with cardiac only phenotypes affect calcium- and voltage-dependent inactivation but mutations in patients with cardiac and neurological phenotypes also affect channel activation. This is an important step to understand the pathology of Timothy syndrome and paves the way for therapeutic intervention.
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Cranefield Postdoc and Student Awards